Apheresis utility for a given disease

February 20, 2013 in Resources

Category I

Diseases in which therapeutic apheresis has been shown to be effective.

  • Myasthenia Gravis (acute exacerbation or pre-thymectomy)
  • Eton-Lambert Syndrome
  • Coagulation Factor Inhibitors
  • Post-Transfusion Purpura
  • Refsum’s Disease
  • Goodpasture’s Syndrome
  • Autoimmune Haemolytic Anemia(cold antibody type)
  • Symptomatic Cryoglobulinemia
  • Pemphigus Vulgaris
  • Poisoning with Non-Dialysable Protein Bound Toxins
  • Sickling Disorders-acute chest syndrome, resistant priapism, stroke(red cell exchange)
  • Severe symptomatic thrombocytosis (plateletpheresis)
  • Chronic Inflammatory Demyelinating Polyneuropathy
  • Plasma Hyperviscosity Syndrome
  • Myeloma Kidney (light chain disease)
  • Paraprotein Associated Peripheral Neuropathy
  • Acute Guillain-Barre Syndrome
  • Thrombotic Thrombocytopenic
  • Purpura/Haemolytic Uremic Syndrome

Category II

Diseases in which the role of therapeutic apheresis is unclear or is under active study.

  • Systemic Lupus Erythematosus
  • Systemic Vasculitis (other than SLE)
  • Familial Hypercholesterolemia
  • Immune Thrombocytopenic Purpura
  • Sezary Syndrome (extracorporeal photopheresis)
  • Severe Rh Sensitized Pregnancy
  • Peripheral Neuropathy Associated with the Acquired Immune Deficiency Syndrome

Category III

Diseases in which therapeutic apheresis has not been shown to be effective.

Multiple Sclerosis

  • Renal Transplant Rejection
  • Polymyositis/Dermatomyositis
  • Amyotrophic Lateral Sclerosis
  • Fulminant Hepatic Failure
  • Schizophrenia
  • Idiopathic Rapidly Progressive Glomerulonephriti